Design is a way of communication and expression. Words, shapes and images are a language and all together contribute to an effective communication. Designers and creative media labs have focused on the design of printing artifacts for years and in order to stay in the market, the same people adjusted their design skills for cross platform use. This paper discusses the various factors that affect the design of the layout for cross platform publications, the technical specifications and the differentiations in the process of the elements that are beingused, the psychology of the user and the way designers should face the layout design for new technologies. Design is the most important factor for the future reader’s / user’s judgment on whether a printed artifact or a new media application is interesting, and worth spending time on.